abstract：:Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lipsi R,Rogliani P,Calzetta L,Segreti A,Cazzola M

更新日期：2014-12-12 00:00:00

abstract：:Though the guidelines for the optimal management of chronic obstructive pulmonary disease (COPD) following an acute exacerbation (AE) are well established, issues associated with poor adherence to nonpharmacological interventions such as self-management advice and pulmonary rehabilitation will impact on hospital readm...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Harrison SL,Goldstein R,Desveaux L,Tulloch V,Brooks D

更新日期：2014-10-29 00:00:00

abstract：OBJECTIVE:To determine the characteristics of undiagnosed chronic obstructive pulmonary disease (COPD) in a senior community center. METHODS:We performed a cross-sectional, observational study with the following procedures: questionnaire to record demographic and health status data, anthropometry, questionnaire about ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Santos SR,Lizzi ES,Vianna EO

更新日期：2014-10-15 00:00:00

abstract：OBJECTIVES:To explore the mediating role of protein interleukin-6 (IL-6) on the relationship between forced expiratory volume in 1 second (FEV1) and 6-minute walk distance (6MWD) and, further, to determine whether status variables (such as age, sex, and body mass index [BMI]) operate as moderators of this mediation rel...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Baldi S,Jose PE,Bruschi C,Pinna GD,Maestri R,Rezzani A,Bellinzona E,Fracchia C,Dacosto E,Crotti P,Montemartini S

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are both common diseases that coexist frequently. Patients with both diseases have worse stable state health status when compared with patients with one of these diseases. In many outpatient clinics, health status is monitored routinely in C...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Berkhof FF,Metzemaekers L,Uil SM,Kerstjens HA,van den Berg JW

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Despite the availability of national and international guidelines, evidence suggests that chronic obstructive pulmonary disease (COPD) treatment is not always prescribed according to recommendations. This study evaluated the current management of patients with COPD using a large UK primary-care database. ME...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Price D,West D,Brusselle G,Gruffydd-Jones K,Jones R,Miravitlles M,Rossi A,Hutton C,Ashton VL,Stewart R,Bichel K

更新日期：2014-08-27 00:00:00

abstract：BACKGROUND:The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is a recently described entity associating upper-lobe emphysema and lower-lobe fibrosis. We sought to evaluate differences in pulmonary function between CPFE patients with and without airflow obstruction. SUBJECTS AND METHODS:Thirty-one CPFE p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kitaguchi Y,Fujimoto K,Hanaoka M,Honda T,Hotta J,Hirayama J

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) seem to have several symptoms in common that impact health. However, methodological differences make this difficult to compare. AIM:Comparisons of symptoms, impact of symptoms on function and health between patients w...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Theander K,Hasselgren M,Luhr K,Eckerblad J,Unosson M,Karlsson I

更新日期：2014-07-18 00:00:00

abstract：:Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular cha...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Primiani A,Dias-Santagata D,Iafrate AJ,Kradin RL

更新日期：2014-05-24 00:00:00

abstract：BACKGROUND:The causal association between depression, anxiety, and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD) is unclear. We therefore conducted a systematic review of prospective cohort studies that measured depression, anxiety, and HRQoL in COPD. METHODS:Electronic databas...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Blakemore A,Dickens C,Guthrie E,Bower P,Kontopantelis E,Afzal C,Coventry PA

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:Pneumonia poses a significant risk in patients with moderate to severe chronic obstructive pulmonary disease but data are limited on the disease phenotypes most susceptible to pneumonia. METHODS:Cluster analysis using a data-driven recursive partitioning algorithm was employed using baseline data from two p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： DiSantostefano RL,Li H,Hinds D,Galkin DV,Rubin DB

更新日期：2014-05-07 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease in the world, and its associated health burdens and costs are mounting. Until recently, it was generally accepted that targeting the diagnosis of COPD early in its course was a relatively fruitless effort, since treatments other than ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Csikesz NG,Gartman EJ

更新日期：2014-02-27 00:00:00

abstract：:Currently, there is no cure for chronic obstructive pulmonary disease (COPD). The limited efficacy of current therapies for COPD indicates a pressing need to develop new treatments to prevent the progression of the disease, which consumes a significant amount of health care resources and is an important cause of morta...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Caramori G,Chung KF,Adcock IM

更新日期：2014-02-24 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease with an increasing prevalence worldwide. Its potential consequences, including reduced function and reduced social participation, are likely to be associated with decreased health-related quality of life (HRQoL). However, illness percept...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bonsaksen T,Haukeland-Parker S,Lerdal A,Fagermoen MS

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, the similarities and differences in clinical presentation between smokers and nonsmokers are not fully described in patients with COPD. This study was designed to address this issue in a general teaching hospital in the...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang J,Lin XF,Bai CX

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD). METHODS:This was a retrospective case...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mapel DW,Marton JP

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:While cross-national studies have documented rates of chronic obstructive pulmonary disease (COPD) misdiagnosis among patients in primary care, US studies are scarce. Studies investigating diagnosis among uninsured patients are lacking. OBJECTIVE:The purpose of this study is to identify patients who are o...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ghattas C,Dai A,Gemmel DJ,Awad MH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The combination of umeclidinium (UMEC), a long-acting muscarinic receptor antagonist, and vilanterol (VI), a selective long-acting β₂ agonist, is in development for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the pharmacokinetics, safety and tolerability, and pharmacod...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mehta R,Kelleher D,Preece A,Hughes S,Crater G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been associated with an increased risk of pneumonia in controlled clinical trials and case-control analyses. OBJECTIVE:Using claims databases as a research model of real-world diagnosis and treatment, to det...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Yawn BP,Li Y,Tian H,Zhang J,Arcona S,Kahler KH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In patients with acute hypercapnic respiratory failure (AHRF) during exacerbations of COPD, mortality can be high despite noninvasive ventilation (NIV). For some, AHRF is terminal and NIV is inappropriate. However there is no definitive method of identifying patients who are unlikely to survive. The aim of t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Haja Mydin H,Murphy S,Clague H,Sridharan K,Taylor IK

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Pulmonary emphysema causes several electrocardiogram changes, and one of the most common and well known is on the frontal P-wave axis. P-axis verticalization (P-axis > 60°) serves as a quasidiagnostic indicator of emphysema. The correlation of P-axis verticalization with the radiological severity of emphys...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chhabra L,Chaubey VK,Kothagundla C,Bajaj R,Kaul S,Spodick DH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Prediction of future exacerbations of chronic obstructive pulmonary disease (COPD) is a major concern for long-term management of this disease. AIM:To determine which of three multidimensional assessment systems (the body mass index, obstruction, dyspnea, and exercise capacity [BODE] index; dyspnea, obstruc...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Motegi T,Jones RC,Ishii T,Hattori K,Kusunoki Y,Furutate R,Yamada K,Gemma A,Kida K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pasquale MK,Sun SX,Song F,Hartnett HJ,Stemkowski SA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

更新日期：2012-01-01 00:00:00

abstract：:The landmark study of Fletcher and Peto on the natural history of tobacco smoke-related chronic airflow obstruction suggested that decline in the forced expiratory volume in the first second (FEV(1)) in chronic obstructive pulmonary disease (COPD) is slow at the beginning, becoming faster with more advanced disease. T...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tantucci C,Modina D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F) fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). METHODS:Two 52-week, multicenter, double-blin...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tashkin DP,Doherty DE,Kerwin E,Matiz-Bueno CE,Knorr B,Shekar T,Gates D,Staudinger H

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Chronic obstructive pulmonary disease (COPD) related to wood smoke exposure is characterized by important inflammation of the central and peripheral airways without significant emphysema. The objective of this study is to describe the bronchial hyperresponsiveness (BHR) level in women with COPD related to wood ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： González-García M,Torres-Duque CA,Bustos A,Jaramillo C,Maldonado D

更新日期：2012-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Current therapies confer partial benefits either by incompletely improving airflow limitation or by reducing acute exacerbations, hence new therapies are desirable. In the absence of robust early predictors of clinical efficacy, ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： van der Merwe R,Molfino NA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It was reported that autonomic nervous system function is altered in subjects with chronic obstructive pulmonary disease (COPD). We evaluated short- and long-term fractal exponents of heart rate variability (HRV) in COPD subjects. PATIENTS AND METHODS:We analyzed data from 30 volunteers, who were divided in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Carvalho TD,Pastre CM,de Godoy MF,Fereira C,Pitta FO,de Abreu LC,Ramos EM,Valenti VE,Vanderlei LC

更新日期：2011-01-06 00:00:00

abstract：INTRODUCTION:Effects of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) patients with severely impaired health status are poorly documented since these patients are usually excluded from clinical trials. This retrospective, observational study aims to study the impact of disease on health ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： van Ranst D,Otten H,Meijer JW,van 't Hul AJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Polypharmacy of respiratory medications is commonly observed in patients with chronic obstructive pulmonary disease (COPD). The aims of this study were to investigate determinants of polypharmacy and to study the consistency of actual respiratory drug use with current Global Initiative for Chronic Obstructiv...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Franssen FM,Spruit MA,Wouters EF

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:This study was conducted to determine COPD severity at the time of diagnosis as confirmed by spirometry in patients treated in a US managed care setting. PATIENTS AND METHODS:All patients with one or more inpatient stays, one or more emergency department visits, or two or more outpatient visits with diagnosis ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mapel DW,Dalal AA,Blanchette CM,Petersen H,Ferguson GT

更新日期：2011-01-01 00:00:00

abstract：:We hypothesized that bronchodilator treatment not only improves hyperinflation and endurance capacity but also muscular efficiency in stable chronic obstructive pulmonary disease (COPD). We aimed to demonstrate that tiotropium and salmeterol improve muscular efficiency compared with placebo. Twenty-five COPD patients ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： van der Vaart H,Postma DS,Grevink R,Roemer W,ten Hacken N

更新日期：2011-01-01 00:00:00

abstract：:Bronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat(®) Soft Mist™ Inhaler (SMI). We retrospe...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hodder R,Pavia D,Lee A,Bateman E

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Circulating markers of inflammation in chronic obstructive pulmonary disease (COPD) may correlate to disease progression and extrapulmonary complications such as malnourishment. However, surprisingly little is known about gender-related differences for circulating inflammatory markers in COPD. PURPOSE:To ch...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Larsson S,Nordenson A,Glader P,Yoshihara S,Lindén A,Slinde F

更新日期：2011-01-01 00:00:00

abstract：:Visual and auditory analysis of respiratory sound signals promises improved detection of certain types of lung diseases. LabVIEW software was used to design a system that monitors the respiratory activity of the patient. The program developed calculates the respiratory rate, displays the time expanded waveform of the ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sahgal N

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether long-term intermittent azithromycin therapy reduces the frequency of exacerbation in severe chronic obstructive pulmonary disease (COPD). METHODS:We retrospectively investigated the clinical benefits of long-term azithromycin (500 mg orally three times per week...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pomares X,Montón C,Espasa M,Casabon J,Monsó E,Gallego M

更新日期：2011-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease of the lung caused primarily by exposure to cigarette smoke. Clinically, it presents with progressive cough, sputum production, dyspnea, reduced exercise capacity, and diminished quality of life. Physiologically, it is characterized by...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sharafkhaneh A,Mattewal AS,Abraham VM,Dronavalli G,Hanania NA

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES:this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Balint B,Watz H,Amos C,Owen R,Higgins M,Kramer B,INSURE Study Investigators.

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Dry powder inhalers (DPIs) are inspiratory flow driven and hence flow dependent. Most patients with chronic obstructive pulmonary disease (COPD) are elderly and have poor lung function. The factors affecting their inspiratory flows through inhalers are unclear. OBJECTIVE:To study peak inspiratory flows (PIF...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Malmberg LP,Rytilä P,Happonen P,Haahtela T

更新日期：2010-08-09 00:00:00